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The limitation is individual variability

B12 supplements come in multiple forms, one being an over the counter orally ingested pill

doi: 10.2353/ajpath.2009.080804 31

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The discovery of mutation in the SC5NA gene encoding a sodium channel ion, which is associated with abdominal pain experienced by IBS patients, was a notable example of the ability of gene aberration to induce IBS clinical symptoms (Beyder et al., 2014)

Yang Y.L